Ex-erythrocytic schizophrenia

(i) Schizont: Cryptomerozoites invade new liver cells. Grows in size by consuming food and divides repeatedly to form numerous nuclei. This multinucleated condition is called zygote.
(ii) Metacryptomerozoite: Cytoplasm accumulates around each nucleus of the zygote to form new cells. The cells are called metacryptomerozites. Metacryptomerozites are of two types. Micrometacryptomerozites and macrometacryptomerozites. Micrometacryptomerozotes are small in size and have large nuclei. Macrometacryptomerozotes are large in size and have small nuclei. Macrometacryptomerozites invade new liver cells. Micrometacryptomerozoites enter the bloodstream and invade red blood cells. From sporozoite to metacryptomerozote takes 7-10 days. Merozoites can undergo zygogy in liver cells for years without showing any symptoms of malaria.

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