Arrival of phagocytes in the infected area (Infection): Chemicals such as histamine, kinin, prostaglandin are produced in the infected area of the body. Due to these chemicals, phagocyte cells (macrophages and neutrophils) are stimulated and accumulate at the wound site. This process is called chemotaxis.
Adherence to microbes: Phagocyte cell membrane contains receptor material. Phagocytes attach to microbes with the help of receptor substances.
Germ eating (Ingestion): Phagocytes surround the germs by making passageways. The cavity formed in it is called phagosome. Phagocytes ingest microbes by forming phagosomes.
Formation of phagolysosome (Phagolysome): Phagosomes are located individually in the cytoplasm of the cell. Lysosomes fuse with phagosomes to form sac-like structures. It is called phagolysosome.
Bacterial death and digestion (Killing): Inside the phagolysosome, the lysosome secretes bactericidal proteolytic enzymes. This enzyme destroys bacteria. Bacteria die within 10-30 minutes of ingestion.
Discharge: After destroying the bacteria, the neutrophils die and are released as pus. Macrophages destroy new bacteria by releasing toxic and indigestible parts.