Genes or DNA located in chromosomes carry all the signals of the cell. It initiates cell division by signaling. DNA replication completes preparations for cell division. Cell division does not begin unless DNA is replicated. Hence, chromosomes play an important role in cell division. Replication, duplication, division and polarization of chromosomes are prerequisites for cell division. Cells without chromosomes never divide. Abnormal distribution of chromosomes during cell division has adverse effects on cell characteristics and survival. So it can be said that chromosomes play a direct role in cell division. Cell division will be mitosis or meiosis depending on how many times the chromosomes divide.