1. Early symptoms of the disease
(i) Nausea occurs. Sometimes there is vomiting.
(ii) Headache and insomnia.
(iii) Loss of appetite and aversion to food.
(iv) Muscle pain and joint pain.
(v) The body feels cold.
(vi) Very thirsty.
(vii) Patient takes less food and becomes weak.
(viii) Difficulty breathing.
(ix) The patient is constipated.
2. Secondary symptoms of the disease
(i) Fever with chills and rigors after 48 hours.
(ii) Intermittent fever and discharge of fever with sweat.
(iii) 2-3 days after each other.
(iv) Fever usually occurs in the morning and afternoon.
(v) Three conditions of malarial fever are noteworthy. Cold condition, heat condition and sweating condition.
(vi) Body temperature is lower than normal when fever is gone. It is cold. Cold conditions last from 20 minutes to 1 hour.
(vii) Body temperature is very high in heat condition and temperature is up to 104-105 degrees Fahrenheit. This condition lasts for 2-4 hours.
(viii) Excretes toxins through sweat. The sweat condition lasts for 2-3 hours.
3. Final symptoms of the disease
(i) Red blood cells are destroyed. Anemia occurs. In this condition, hemolytic anemia occurs.
(ii) Spleen and liver of the patient become swollen and enlarged day by day. Lysolecithin is secreted from the spleen.
(iii) Parasites produce antibodies called Haemolysin which destroy red blood cells.
(iv) Digestion of the patient is disturbed.
(v) Patient may die due to brain damage.