1. At the end of zygogy, the merozoites break through the red blood cell wall and come out. This results in destruction of red blood cells and anemia.
2. Liver and spleen become inflamed or swollen in a malaria patient. In this condition, the production of red blood cells in the patient’s body is inhibited. Due to this, the patient becomes anemic.
3. Analytic substance called Lysolecithin is secreted from the spleen of malaria patients. All these substances destroy red blood cells. It causes anemia.
4. The malaria parasite produces a type of antibody called Heamolysin. These antibodies destroy healthy RBCs. The patient becomes anemic.
5. The patient has displeasure and reluctance to take food. It lacks nutrients and does not produce blood cells.