1. Malaria Fever: Human red blood cells secrete toxic substances called hemogenes during the erythrocytic zygogy cycle. Hemogenes cause body temperature to rise and fever with chills. It is called malarial fever. It is a deadly disease. It can cause the death of the patient.
2. Liver cell destruction: Malaria parasite sporozoites enter human liver cells through mosquito saliva. After entering the liver cells, the sporozoites take food and grow in size and transform into cryptozoites. The nucleus of the cryptozoite divides into numerous nuclei. It’s called Saigeant. Cytoplasm accumulates around each nucleus of the zygote to form a cryptomerozoite. Cryptomerozoites break through the hepatocyte wall and come out by destroying the hepatocytes.
Each cryptomerozoite formed invades new liver cells and enlarges by consuming food. Its nucleus divides to form numerous nuclei. It’s called a saizont. Cytoplasm accumulates around each nucleus of the zygote and metamorphoses into a metacryptomerozoite. When the metacryptomerozotes metamorphose, they break through the hepatocyte wall and come out by destroying the hepatocytes. In this way, liver destruction is obtained one after the other.
3. Destruction of red blood cells: Merozoites of the malaria parasite enter human red blood cells through plasma. After entering the red blood cells, the merozoites take food and grow in size and transform into trophozoites. The signet ring is formed from the trophozoite. The shape of the signet ring changes and takes on an indefinite shape like an amoeba. It is called amoeboid trophozoite. The amoeboid trophozoite then changes shape and becomes spherical. Its nucleus divides into numerous nuclei. This condition is called cysont. Cytoplasm accumulates around each nucleus of the zygote to form a merozoite. Merozoites are released by breaking the red blood cell wall and destroying the red blood cell. Each merozoite formed attacks and destroys red blood cells again. Thus the red blood cells are destroyed.
Liver cells and red blood cells are successively destroyed by the malaria parasite, leading to anemia in the host and eventual death of the host.