Transgenic animals are used as bioreactors to produce drugs from their milk, blood and urine. This is called molecular farming. These medicines are used to cure many diseases. TPA is obtained from the milk of transgenic goats developed in America.
What is gene therapy?
Curing genetic disorders is not an easy task. However, it has been possible to cure this disease in the process of gene therapy. Viruses modified in the process of genetic engineering are used in the process of gene therapy.
Gene engineering to prevent pulmonary emphysema
Emphysema is a deadly lung disease. AAT protein is used to prevent this disease. AAT protein is being produced commercially by genetic engineering. So prevention of lung emphysema is only a matter of time.
Recombinant DNA in growth hormone production
The human growth hormone somatotrophin is produced commercially by recombinant DNA technology. It is used in the treatment of dwarfism. 6-10 mg of growth hormone per week increases height by more than 6 cm in the first year.
Gene engineering in interferon production
Interferon is a high molecular weight protein. It inhibits the growth of cancer cells and inactivates viruses. Interferon is produced from E. coli and yeast through genetic engineering. It is used in the treatment of hepatitis-B, herpes, papilloma, rabies etc. Interferon was discovered in 1957 by Alec Isaacs and Jean Lindenman.
What is insulin?
Insulin is a type of hormone. Insulin is commercially produced using recombinant DNA technology. It controls diabetes in humans by accelerating blood glucose uptake levels. So diabetics take insulin.
Recombinant DNA in the treatment of hereditary diseases
Hereditary diseases are difficult to cure. Antithrombin-III from transgenic goat milk and III C12 esterase inhibitor drugs from transgenic rabbit milk have been developed by recombinant DNA technology. Antithrombin-III drugs are used in the treatment of human antithrombin deficiency and III C12 esterase inhibitor drugs in the treatment of human angioedema. Efforts are underway to eradicate hereditary diseases by discovering more drugs through this technology. Each human cell contains up to 25,000 (many more are unknown) functional genes. A disorder in one of the genes can cause the disease. About 3500 genetic disorders are known in human body. This disease can be cured by recombinant DNA technology.
Genetic Engineering for Vaccines
Gene engineering technology is used to produce vaccines or vaccines for various diseases. These vaccines are used to treat infectious diseases like Measles, Polio, Smallpox, Tuberculosis, Rabies, Cholera, Mumps, Hepatitis-B etc. At present, efforts are being made to make effective vaccines for various diseases including corona. It will be possible to ensure the protection of human health by discovering new vaccines.
Role of recombinant DNA in stress resistant cultivars
(i) Pyrroline-5 Carboxylase Synthase gene isolated from soybean and inserted into tobacco plant was found to grow ten times more in saline soil.
(ii) Cold tolerant AF gene isolated from arctic fish (Flounder) and introduced into crop plants to create cold tolerant crops. For example, tomatoes, round potatoes etc.
(iii) Drought resistant Bhutra has been developed by introducing csPB gene from Bacillus subtilis bacterium into Bhutra plant.
(iv) Introgression of the At NHXI gene from Arabidopsis into peanut plants has resulted in salted peanuts.
(v) Genes resistant to stresses such as heat, cold, heavy metals, phytohormones etc. have been identified in natural environment. All these genes are trying to enter the plant body.
Development of weed resistant plants
Application of herbicides on land causes extensive damage to crop plants. Transgenic plants have been created by separating the Bar gene from bacteria called Streptomyces and applying it to tomato, potato, tobacco, bhutra, wheat etc. These transgenic plants can resist the herbicide phosphinothricin.